Syllabus Information

5.1. Methodological overview

Planned competences will be acquired through the following activities:

- Classroom lectures (4 ECTS).

- Laboratory sessions (1 ECTS)

5.2. Learning tasks

Different activities are planned that will help students to achieve the objectives:

-       Classroom lectures according to the program described in point 5.3

-       Laboratory sessions that include some of the techniques previously explained in classroom lectures.

-       An optional essay about a topic chosen among a list proposed by the teacher.  The student will be guided through the process of bibliographic search and writting.

5.3. Syllabus

Transport and biotransformations

Transport of xenobiotics across biological membranes: Types and biochemical mechanisms. Enzymes as drug targets. DNA as drug target. Other targets. Biotransformation of xenobiotics. Activation and inactivation. Phase I and Phase II transformations. Response and adaptation of xenobiotics.

 Toxicity of chemical contaminants

Molecular mechanisms of toxicity. Cell effects of xenobiotics. Cell damage. Mutagenesis. Ames test and SOS chromotest in the evaluation of mutagenic potential.

 Mechanism of action of drugs

General aspects of pharmacological drugs. Antimicrobials. Antitumoral drugs. Drugs acting on the nervous system. Other

drugs.

 Drug development

Pharmacological targets. Preclinical phase. Clinical essays

5.4. Course planning and calendar

For further details concerning the timetable, classroom and further information regarding this course please refer to the"Facultad de Ciencias " website and Moodle2 platform.

5.5. Bibliography and recommended resources